- November 2024 – We are delighted to have contributed to research by Guy Karlebach from the Robinson Lab at JAX who identified that alternative splicing is coupled to gene expression in a subset of variably expressed genes published in npj Genomic Medicine. Read the full story.
- October 2024 – Brittany Angarola’s paper entitled ‘Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer’ is accepted in Nature Aging.
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This collaborative work with the Ucar lab at JAX reveals how aging rewires the cellular composition of mouse mammary tissues and impacts the transcriptomic and epigenomic programs of mammary epithelial, fibroblast, and immune cells, identifying shared signatures of aging and cancer.
- October 2024 – our work on RNA splicing in meningioma is featured on the Neuro-Oncology Podcast, hosted by Evan Noch from UTSW. http://soc-neuro-onc.libsyn.com/alterations-in-rna-splicingbetween-meningioma-dna-methylation-groups
- September 2024 – We are delighted to have contributed to research by Tima Karginov from the Vella Lab at UCHC which revealed a role for the TRA2β poison exon in programing T cell fate in response to antigen-receptor stimulation published in Science. Read the full paper.
- August 2024 – Nathan Leclair’s paper entitled ‘The RNA-binding protein IGF2BP1 regulates stability of mRNA transcribed from FOXM1 target genes in Hypermitotic meningioma’ is accepted in Acta Neuropathologica.
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In collaboration with the Raleigh Lab at USCF we show that the RNA binding protein IGF2BP1 regulates meningioma cell growth, and that its expression stratifies patient outcomes and may be utilized as a risk marker. Read the full story
- August 2024 – our Roadmap Article entitled ‘Steering research on mRNA splicing in cancer towards clinical translation’ is accepted in Nature Review Cancer.
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This multi-institutional white paper which stemmed from a Forbeck Forum [add link] discusses the current technological challenges, lingering misconceptions, and outstanding questions that hinder clinical translation of the splicing vulnerabilities that exist in tumors. Read the full.
- Juy 2024 – Nathan Leclair’s paper entitled ‘RNA splicing as a biomarker and phenotypic driver of meningioma DNA methylation groups’ is accepted in Neuro-Oncology.
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This collaboration with the Raleigh Lab at USCF uncovers that RNA splicing is an important driver of meningioma phenotypes that can be useful in prognosticating patients and as a potential exploit for therapeutic vulnerabilities. Read the full story.